Drug Utilization Pattern and Adverse Drug Reaction Monitoring of
Antibiotics Use in Ear, Nose and Throat Infection at Tertiary Care
Hospital, Lucknow, India
Objective: To investigate the ENT department’s (OPD, IPD) antibiotic
prescribing practices at a tertiary care hospital in Lucknow, India.
Material and Methods: A prospective, cross-sectional, non-experimental
(observational) study was performed in (OPD, IPD) department of Ear,
Nose and Throat (ENT) over a period of 6 months.
Result: In this study,
100 ENT patients (51 male, 49 female) were selected based on inclusion
and exclusion criteria. Ear infections were the most common reason for
visits (86 patients), followed by nose (7 patients) and throat
infections (5 patients). The most commonly prescribed antibiotics were
β-lactam antibiotics, with penicillin’s (amoxicillin with clavulanic
acid) and cephalosporin’s (cefixime) being the most commonly used.
Combination therapy was used in 117 patients, with an average of 1.9
antibiotics per patient per course. A total of 40 antibiotics were
prescribed, with oral being the most common route of administration.
Only one adverse drug reaction was reported, with a suspected link to
cefixime causing an increase in rashes in one patient. The study
population had comorbid conditions of anxiety, epilepsy, and anaemia.
Conclusions: To conclude, our study in the university teaching hospital
(IIMSR) highlighted lesser utilization of antibiotics in ENT infections,
as some of the ENT infections are not due to bacteria. The majority of
ENT patients admitted to the hospital appear to have bacterial
infections, and most of them reacted favourably to antibiotic treatment.
Majority of the patients used the regimen in accordance with the current
Keywords: Antibiotic agents, drug utilization, adverse drug
reaction, ENT infection.