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Increased Women’s Cardiovascular Mortality in their forties after Hypertensive Disorders of Pregnancy: A national cohort study
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  • Sophie Welters,
  • Pim Teunissen,
  • Anita Ravelli,
  • Wietske Hermes,
  • Christianne de Groot
Sophie Welters
Amsterdam UMC
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Pim Teunissen
Amsterdam UMC
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Anita Ravelli
Amsterdam UMC - Locatie AMC
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Wietske Hermes
Medisch Centrum Haaglanden Westeinde
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Christianne de Groot
Amsterdam UMC
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Peer review status:UNDER REVIEW

16 Apr 2020Submitted to BJOG: An International Journal of Obstetrics and Gynaecology
29 Jun 2020Assigned to Editor
29 Jun 2020Submission Checks Completed
30 Jun 2020Reviewer(s) Assigned


Objective: To determine the association between HDP and cardiovascular mortality. Design: Cohort study Setting: Population based using the Dutch National Birth Hospital Registry linked with the National Death Registry. Population: All women who gave birth between 1995 – 2015 Methods: Cox-regression models with hazard ratios (HR) and survival curves were executed. Main outcome and measures: The cardiovascular mortality risk after HDP was analyzed. Cardiovascular mortality-risk was analyzed in women with a history of HDP in one or more pregnancies compared to women without a history of HDP. In a subgroup of this cohort the effect of HDP on cardiovascular mortality was analyzed using only the nulliparous pregnancy of women. Results: Women were followed for a mean time of 10.4 years. Of 1,625,246 parous women 21.9% had a history of HDP. Gestational hypertension (18.1%) was associated with an aHR of 2.13 (95% CI: 1.91 – 2.38) for CVM. Preeclampsia (3.8%) was associated with an aHR of 3.35 (95 %CI: 2.80 – 4.00) for CVM. Cardiovascular mortality risk was highest in women with a history of HDP combined with a preterm birth (<37 weeks) and a growth restricted child (