loading page

Use of 68Ga-DOTATATE PET/CT imaging for staging evaluation of Neuroblastoma in the COVID 19 Pandemic: Potential for clinical use
  • Ata Maaz,
  • Jim O'Doherty,
  • Mehdi Djekidel
Ata Maaz
Sidra Medical and Research Center
Author Profile
Jim O'Doherty
MSD Translational Medicine Research Centre
Author Profile
Mehdi Djekidel
Sidra Medical and Research Center
Author Profile

Abstract

Background: MIBG imaging has been the standard for neuroblastoma staging following its discovery 4 decades ago. Novel agents such as 18F-FDOPA and 68Ga-DOTATATE are being widely used nowadays in academic centers. In the midst of the COVID-19 pandemic, procurement of MIBG has proved particularly challenging, necessitating the use of 68Ga DOTATATE positron emission tomography. Methods: 68Ga-DOTATATE PET/CT imaging was carried out for completion of staging investigation for three pediatric patients who were diagnosed with Neuroblastoma at our institution, as 123Iodine MIBG became unavailable during the pandemic. Results: 68Ga-DOTATATE PET/CT scans were carried out in all three pediatric patients without any complications. All patients showed 68Gallium DOTATATE avid disease. PET/CT scans showed better spatial resolution, increased lesion contrast and demonstrated high accuracy in staging neuroblastoma patients in concordance with current EANM guidelines. Conclusion: 68Ga-DOTATATE PET/CT imaging can be reliably used as an alternative to MIBG for staging and evaluation of patients with neuroblastoma. Impact may be best in high risk disease.