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Differential diagnostic challenges during the Covid-19 pandemic for pediatricians in an Eastern European country where newborn screening of cystic fibrosis is not available: A case report
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  • Szofia Hajósi-Kalcakosz,
  • Borbála Zsigmond,
  • Andrea Párniczky,
  • Reka Bodnar
Szofia Hajósi-Kalcakosz
Heim Pál Gyermekkórház
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Borbála Zsigmond
Heim Pál Gyermekkórház
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Andrea Párniczky
Heim Pál Gyermekkórház
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Reka Bodnar
Heim Pál Gyermekkórház
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Abstract

Newborn screening (NBS) of cystic fibrosis (CF) is not available currently in Hungary. Pediatricians should be able to recognize the illness based on the symptoms alone. Lack of NBS causes differential diagnostic challenges for physicians and delayed diagnosis of CF. We present a case of a two-year-old girl who was transferred to our hospital as a suspected Covid-19 patient with one week history of fever and coughing in March 2020. As Covid-19 was excluded, the severity of the clinical picture pointed towards an acute exacerbation of an underlying chronic condition. Her symptoms such as tachypnea, wheezing, lung crackles, hepatomegaly and clubbing of the fingers were all consistent with undiagnosed CF. In the end, sweat chloride level and genetic test verified the diagnosis. This case emphasizes the need of NBS in Hungary.