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The Role of Urine Biochemical Parameters for Predicting Disease Severity In COVID-19 Patients
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  • omer erdogan,
  • fesih ok,
  • Serkan Carkci,
  • emrullah durmus
omer erdogan
Siirt Training and Research Hospital
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fesih ok
Siirt Training and Research Hospital
Author Profile
Serkan Carkci
Siirt Training and Research Hospital
Author Profile
emrullah durmus
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Abstract

Background: We aimed to determine the importance of urinary biochemical parameters in predicting the severity of COVID-19 disease. Methods: Totally 133 individuals diagnosed with COVID-19 in our clinic were included in the study. The groups were formed according to the severity of COVID-19 disease (moderate 85, severe 29, and critical 19), and an additional control group was created from 50 healthy individuals. The correlation between urine biochemical parameters and the severity of disease was investigated. Results: Erythrocyturia, proteinuria, and glucosuria rates were significantly higher in patients than controls. In patients, the median urine specific gravity (SG) value was found to be lower (p<0.001), and median potential of hydrogen (pH) value was found to be higher compared to the controls (p<0.001). In the severe group age, erythrocyturia, proteinuria, and glucosuria were significantly higher than the non-severe group. On multivariate analysis, proteinuria (OR: 4.66, 95%CI 1.02-21.4, p=0.047) and age (OR: 1.06, 95% CI 1.03-1.10, p<0.001) were independent predictive factors for disease severity. Conclusion: Some urine biochemical parameters especially proteinuria and advanced age may be useful for predicting the COVID-19 disease severity.

Peer review status:UNDER REVIEW

13 Sep 2020Submitted to International Journal of Clinical Practice
15 Sep 2020Assigned to Editor
15 Sep 2020Submission Checks Completed
16 Sep 2020Reviewer(s) Assigned